Basic Info. Melatonin: Understand the Sleep Hormone and Its Benefits Melatonin is a hormone naturally produced in the body, primarily by the pineal gland, that plays a crucial role in regulating the sleep-wake cycle, also known as the circadian rhythm. It helps the body know when to sleep and when to wake up. Melatonin is also available as a supplement, and it is often taken to help with sleep problems, jet lag, and shift work-related sleep disturbances. ...
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Basic Info. The synthetic peptides corresponding to amino acids 172-191, 176-191, 177-191, 178-191, 179-191, and 180-191 of human growth hormone (HGH) have been studied for their in vivo effects in normal rats. Four of the peptides produced a short-lived rise in blood glucose and a more sustained rise in plasma insulin, whereas the other two (HGH 179-191 and 180-191) were inert in the systems tested. A single dose of the peptides containing the amino acids sequence 178-191 of the hGH molecule significantly reduced insulin sensitivity of the animals in intravenous insulin tolerance tests. The findings also indicate that the biologically active peptides must not only have the minimum of the informational sequence but also that this must be in correct physical configuration. ...
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Basic Info. The original source of Dermorphin is Sauvage's leaf frog , Brazilian orange-legged leaf frog, Jandaia leaf frog. Potent and selective natural opioid that binds as an agonist to ¦̀-opioid receptors. 30¨C40 times more potent than morphine. Antinociceptive effect. Dermorphin is a peptide expressed by the frog venom skin glands with a potent opiate-like activity on mu-type opioid receptors, which have potent depressive and analgesic effects. Dermorphin may also have effects on pulmonary ventilation and pituitary hormone release. Dermorphin is 30-40 times more potent than morphine, however it has never been approved for medical use in humans or animals. ...
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Basic Info. GLP-1 agonists are a class of drugs primarily used for managing type 2 diabetes that have also proven to be helpful for supporting weight loss. These medications work by mimicking the actions of the glucagon-like peptide-1 hormone, aiding in blood sugar regulation and promoting a feeling of fullness. ...
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Basic Info. Botulinum toxin, or botulinum neurotoxin, is a highly potent neurotoxic protein produced by the bacterium Clostridium botulinum. It's known for its ability to block nerve functions, leading to paralysis and is the cause of the disease botulism. Botulinum toxin is also used in small doses in medical and cosmetic applications, such as Botox injections for wrinkle reduction and other conditions. ...
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Basic Info. 5-amino-1MQ is a small molecule drug that functions to block the activity of an enzyme called nicotinamide N-methyltransferase (NNMT). NNMT plays a significant role in metabolism and energy and is predominantly active in fat tissue. By blocking NNMT, 5-amino-1MQ stimulates an increase in nicotinamide adenine dinucleotide (NAD+), a cofactor that is central to cellular metabolism, thereby increasing metabolic rate and activating a gene called sirtuin-1 (SIRT1). SIRT1 is also known as ¡®the longevity gene¡¯ because of its role in reducing the risk of diabetes, obesity, metabolic syndrome, atherosclerosis and other forms of cardiovascular disease, kidney disease, liver disease, neurodegeneration, and cancer. ...
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Basic Info. EPO injection (Erythropoietin Injection) is a medicine that helps your bone marrow to produce more red blood cells.It is used to treat a type of anemia caused by kidney disease. It is also used to treat anemia caused by cancer chemotherapy and by taking medicines to treat HIV. ...
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Basic Info. Cerebrolysin, a neuropeptide preparation, has been extensively studied in rat models to evaluate its potential in treating neurological impairments. Research indicates that Cerebrolysin can significantly enhance cognitive functions and promote neuroprotection following brain injuries. It is rats subjected to mild traumatic brain injury (mTBI) were treated with Cerebrolysin. The results demonstrated notable improvements in long-term spatial learning and memory, as assessed by the Morris water maze test. Additionally, treated rats exhibited reduced accumulation of amyloid precursor protein and decreased astrogliosis, suggesting neuroprotective effects. ...
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Basic Info. ARA 290, a Nonerythropoietic Peptide Engineered from Erythropoietin, Improves Metabolic Control and Neuropathic Symptoms in Patients with Type 2 Diabetes. ARA 290 has been shown to be effective in the reduction of inflammation and activation of the healing process in a wide variety of preclinical models as well as in patients. With respect to diabetes, substantial recent work has shown that rhEPO can improve the diabetic state in animal models . However, in addition to interacting with the innate repair receptor in a paracrine/autocrine manner, EPO also functions as a circulating hormone via its interaction with the EPO receptor homodimer that mediates hematopoiesis. ...
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Basic Info. Cagrilintide, a long-acting analogue of the hormone amylin, presents a promising new approach to tackling obesity. Unlike many weight-loss drugs that only target one mechanism, cagrilintide works on multiple fronts. It suppresses appetite by promoting feelings of fullness (satiety) and slows down gastric emptying, making people feel full for longer periods of time. Early trials of cagrilintide have shown that it leads to significant weight loss compared to placebo and even other peptides like liraglutide, which is currently used for obesity treatment. In one study, participants taking cagrilintide lost up to 10.8% of their body weight over 26 weeks, outperforming those on liraglutide. Sustained weight loss like this can help break the cycle of yo-yo dieting. ...
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Basic Info. NAD, the full name of nicotinamide adenine dinucleotide, is an important coenzyme that participates in a variety of metabolic processes in cells, such as energy production, DNA repair, and cell signaling. NAD usually exists in two forms, NAD+ and NADH, which play an important role in electron transfer in cells. NAD is an important coenzyme that participates in a variety of metabolic processes in cells and is essential for health. By supplementing NAD+ or NMN, the level of NAD+ in the body can be increased, thereby improving health and delaying aging. ...
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Basic Info. Alprostadil is in a class of medications called vasodilators. It works by relaxing the muscles and blood vessels in the penis to keep enough blood in the penis so that an erection can occur. Alprostadil does not cure erectile dysfunction or increase sexual desire. ...
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